Psoriatic Arthritis

A pathology of moving parts and pathway interplay

The pathologic processes leading to psoriatic arthritis (PsA) are not yet completely understood. However, studies reveal an intricate interplay of cytokine pathways and cells responsible for initiating and maintaining the chronic inflammation associated with its various clinical manifestations.^1-4

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References

Veale DJ, Fearon U. The pathogenesis of psoriatic arthritis. Lancet. 2018;391(10136):2273-2284.
Bravo A, Kavanaugh A. Bedside to bench: defining the immunopathogenesis of psoriatic arthritis. Nat Rev Rheumatol. 2019;15(11):645-656.
Crispino N, Ciccia F. JAK/STAT pathway and nociceptive cytokine signaling in rheumatoid arthritis and psoriatic arthritis. Clin Exp Rheumatol. 2021;39(3):668-675.
Picchianti-Diamanti A, Spinelli FR, Rosado MM, et al. Inhibition of phosphodiesterase-4 in psoriatic arthritis and inflammatory bowel diseases. Int J Mol Sci. 2021;22(5):2638.

Examining the topography of chronic inflammation in

A pathology of moving parts and pathway interplay

References

Examining the topography
of chronic inflammation in

psoriatic
arthritis